Is there any advantage of one over the other on a basic pc printer, when color seps aren’t involved?
No.
Consumer-grade printers print CMYK (or CcMmYK), but it’s not the same CMYK as commercial offset printing presses use. The cyan in particular is bluer than offset CMYK.
The software that drives consumer inkjet printers expects RGB data. If you send a CMYK image to a consumer printer, the driver software will convert the image to RGB, then back to the printer’s own variety of CMYK. This typically produces inferior results to simply using RGB in the first place.
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