Anti-aliasing type

There seems to be no agreement about anti-aliasing type. Questions to you guys:
1. If I have LARGE type (working at 300 ppi) for viewing on screen that will be flattened, then changed to 72ppi, and saved as part of a jpeg, would you anti-alias (smooth) the type first in the type layers before flattening or leave it with "None" for anti-aliasing?

2. If I have SMALL type (working at 300 ppi) for viewing on screen that will be flattened, then changed to 72ppi, and saved as part of a jpeg, would you anti-alias (smooth) the type first in the type layers before flattening or leave it with "None" for anti-aliasing?

3. For print output, but flattened as part of a Tiff file at resolution 300 ppi, what would you do for large and small type before flattening regarding anti-aliasing?

Thanks.

Can I ask why you work at 300 ppi initially, and later convert to 72? Seems to me that you will always lose some detail when you convert.

I use anti-aliasing all the time, except with pixel fonts being used in their design size.

I am thinking of something that may be used for print and web. Also, I thought I noticed a difference for the screen that way, by having it at 300, the flattening, then pixelating, but under a test I just did, I don't think there is any difference.

If you anti-alias everyrhing, would you do that for print and web (if it is to be a flattened text for a jpeg for the www)?
Have you ever noticed a difference?

Thanks

Anti-aliasing should not be a concern for print. At a resolution of 300 ppi, the resolution is high enough that it should look smooth. But I would leave it on.

Small text on a jpg will look a little blurry. Fact of life. Usually I live with it. If I can't, I would get a pixel font.