Select the crop tool.
You will notice that you can modify the crop tool attributes. This is located above the image and below the menu bar. You can enter 6 and 4 into the height and width for the crop tool.
Crop as you see fit and the cropped portion will end up being the dimensions you specified. You will be constrained to 2:1 proportions as you adjust the crop area.
Hit Enter when your happy with the crop.
That’s it. In most cases this is all you have to do.
One word of warning:
If you select a very small section of the image (which for the sake of argument could be 2 inches by 1 inch) Photoshop will adjust the resolution to make it 6 by 4. The resulting image printed out may look disappointing. In the case where you want a small part of the image to end up much larger but don’t want to sacrifice image quality, then you must upsize the image first before cropping. Be careful to upsize in 10% increments only until the image is large enough to accommodate your crop.
One way to do this, without having to crop anything, or worse, risk upsampling is to simply add some canvas size in white to 3:2 proportions, and leave your original photo intact. You’ll get a larger border on your print, but it will all be there, and at highest possible resolution.
Mac